The Effectiveness Of SSRI Antidepressants Reduced By Anti-Inflammatory Drugs

The Effectiveness Of SSRI Antidepressants Reduced By Anti-Inflammatory Drugs

Scientists at the Fisher Center instead of Alzheimer's Disease Research at The Rockefeller University, led ~ the agency of Paul Greengard, Ph.D., and Jennifer Warner-Schmidt, Ph.D., get shown that anti-inflammatory drugs, that include ibuprofen, aspirin and naproxen, contract the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors, or SSRIs, taken toward depression and obsessive-compulsive disorder and disquiet disorders. This surprising discovery, published online this week in the Proceedings of the National Academy of Sciences, may elucidate why so many depressed patients catching SSRIs do not respond to antidepressant method of treating and suggests that this lack of effectiveness may subsist preventable. The study may be especially momentous in the case of Alzheimer's malady. Such patients commonly suffer from degradation and unless this can be treated favorably, the course of the illness is credible to be more severe. Depression in the somewhat advanced in life is also a risk factor with respect to developing Alzheimer's Disease and researchers be the subject of suggested that treating depression in the somewhat old might reduce the risk of developing the ail.

In the recent study, investigators treated mice with antidepressants in the presence or lack of anti-inflammatory drugs. They therefore examined how the mice behaved in tasks that are sensitive to antidepressant treatment. The behavioral responses to antidepressants were inhibited through anti-inflammatory/analgesic treatments. They therefore confirmed these effects in a human population. Depressed individuals who reported anti-incendiary drug use were much less that may be liked to have their symptoms relieved by an antidepressant than depressed patients who reported nay anti-inflammatory drug use. The issue was rather dramatic since, in the abstraction of any anti-inflammatory or analgesic application, 54 percent of patients responded to the antidepressant, it being the case that success rates dropped to approximately 40 percent because those who reported using anti-incendiary agents.

"The mechanism underlying these movables is not yet clear. Nevertheless, our results may gain profound implications for patients, given the extremely high treatment resistance rates for depressed individuals taking SSRIs," notes Dr. Warner-Schmidt.

Dr. Greengard adds, "Many somewhat advanced in life individuals suffering from depression also esteem arthritic or related diseases and in the same proportion that a consequence are taking both antidepressant and anti-inflammatory medications. Our results suggest that physicians should carefully pair of scales the advantages and disadvantages of continuing anti-tending to inflammation therapy in patients being treated with antidepressant medications."

This research was supported in sub-division by grants from the National Institute of Mental Health and the National Institute ~ward Aging, both parts of the federal government's National Institutes of Health and The Fisher Center on the side of Alzheimer's Research Foundation.