Researchers Uncover Why Ketamine Produces A Fast Antidepressant Response

Researchers Uncover Why Ketamine Produces A Fast Antidepressant Response

UT Southwestern Medical Center scientists are shedding fresh light on why the anesthetic medicine ketamine produces a fast-acting antidepressant reply in patients with treatment-resistant vitiation.

The drug's robust effect at simple doses as a fast-acting antidepressant potentially has use in emergency rooms with high-peril patients.

"Ketamine produces a very meagre increase that immediately relieves depression," uttered Dr. Lisa Monteggia, associate professor of psychiatry at UT Southwestern and more advanced author of the study published June 15 in Nature.

Typical antidepressant medications individual of the most widely prescribed classes of drugs in the U.S. reaped ground year often take several weeks to allay symptoms of depression. If they are not auspicious within 12 weeks, physicians must command a different antidepressant to produce a answer.

"Ketamine produces a fast-acting antidepressant effect, and we hope our investigation provides carping information to treat depression effectively sooner," Dr. Monteggia uttered.

"We now have a novel footway to explore that may provide possible for the development of faster-simulation and longer-lasting antidepressants," Dr. Monteggia afore~.

The next step, Dr. Monteggia afore~, is to investigate further the sententious- and long-term effects of the changes that occur whenever the brain cells communicate with one and the other other.

Other UT Southwestern researchers involved in the study were Anita Autry, observer research assistant in psychiatry; Dr. Megumi Adachi, teacher in psychiatry; Dr. Elena Nosyreva, preceptor in neuroscience; Dr. Elisa Na, postdoctoral researcher in psychiatry; Mr. Maarteen Los, visiting younger researcher in psychiatry; Mr. Peng-fei Cheng, anciently in psychiatry; and Dr. Ege Kavalali, professor of neuroscience and science of the functions of animals and vegetables.