Treating Sleep Apnea In Prediabetes Improves Glucose Levels

Treating Sleep Apnea In Prediabetes Improves Glucose Levels

Optimal manipulation of sleep apnea in patients by prediabetes improves blood sugar (glucose) levels and to this degree can reduce cardiometabolic risk, according to a study presented at the American Thoracic Society International Conference May 17-22, 2013 Philadelphia, Pennsylvania.

"Sleep apnea, a plight associated with breathing disturbances during repose is known to be associated with abnormalities in glucose metabolism, but whether manipulation of sleep apnea has any beneficial effects on glucose metabolism is still in a state of being liable to investigation" said lead author Sushmita Pamidi, MD, of the Department of Medicine at McGill University in Montreal, Canada-"We be favored with studied patients with sleep apnea and prediabetes, a estate defined as higher than normal madcap glucose levels but not high enough to be considered diabetes. We found that optimal treatment of sleep apnea by continuous positive airway pressure (CPAP) according to two weeks led to significant improvements in starch-sugar levels following an oral glucose call for without affecting insulin secretion, suggesting an improvement in insulin sensitivity."

Insulin is a hormone produced in the pancreas that regulates the metabolism of diabetic sugar in the body. Insulin resistance is a situation in which normal amounts of insulin are not correspondent to produce a normal cellular insulin replication to glucose ingestion. Low insulin sensitivity, a share of how sensitive a person's carcass is to the effects of insulin, is associated through the development of type 2 diabetes.

As many as two-thirds of type 2 diabetic patients may be suffering from unrecognized sleep apnea . The power treatment option for sleep apnea is CPAP, in which a machine delivers air at a peculiar pressure via a breathing tube joined to a facemask in order to splint the upper airway begin and prevent further breathing disturbances for the period of sleep. The breathing disturbances during be motionless that result in sleep apnea be in actual possession of been linked to prediabetic conditions of that kind as insulin resistance and glucose intolerance as well as type 2 diabetes and cardiovascular complications.

The current study included 39 adults by sleep apnea and prediabetes who were randomized to couple weeks of either CPAP treatment or placebo small table. Before and after the treatment continuance, study participants underwent an oral starch-sugar tolerance test, a test that measures material substance's ability to use glucose. A sole aspect of the study is that subjects slept reaped ground night in the research laboratory, ensuring optimal adherence to CPAP treatment. Glucose tolerance, insulin secretion, and insulin sensitivity, completely markers for the risk of diabetes, were uniform Subjects were also monitored for the general conception and quality of sleep, 24 sixty minutes blood pressure, heart rate, weight, power expenditure and hormones affecting diabetes dare to undertake.

"Effective treatment of OSA is known to be seized of a positive impact on a tell of important health outcomes and in our study we observed beneficial effects on glucose metabolism," said principal conductor of researches, Esra Tasali, MD, assistant professor of pulmonic and critical care medicine at the University of Chicago. This "demonstration of concept" study may provide vital information for designing larger multicenter clinical trials that faculty of volition determine whether CPAP treatment could exist a first line intervention to hinder or delay the development of sign 2 diabetes. Our study adds to the current the humanities by demonstrating that CPAP treatment of sleep apnea in patients at risk in opposition to developing diabetes may lower this peril, and an assessment for sleep apnea may have existence appropriate as part of the clinical evaluation of patients by prediabetes," said Dr. Pamidi.