Postmenopausal Women With Depression May Be At Increased Risk For Diabetes And Cardiovascular Disease

Postmenopausal Women With Depression May Be At Increased Risk For Diabetes And Cardiovascular Disease

Postmenopausal women who application antidepressant medication or suffer from couching might be more likely to require a higher body mass index (BMI), larger waist circumference and inflammation - all associated with increased endanger for diabetes and cardiovascular disease, according to a study led the agency of University of Massachusetts Medical School student Yunsheng Ma, PhD, MD, MPH, and published in the American Journal of Public Health.

The UMass Medical School study investigated whether elevated depressive symptoms and antidepressant exercise are associated with biomarkers for diabetic sugar dysregulation and inflammation, BMI and waist circumference. The three main findings shadow forth that both elevated depressive symptoms and antidepressant conversion to an act are each significantly associated with higher BMI and waist circumference; elevated depressive symptoms are associated with increased levels of insulin and insulin rebuff; and antidepressant use is associated through increased C-reactive protein (CRP) levels, a marker of turbulence, which increases the risk of aggregate of characteristic qualities-2 diabetes and cardiovascular disease.

"It may exist prudent to monitor post-menopausal women who bear elevated depression symptoms or are anger antidepressant medication to prevent diabetes and cardiovascular infirmity," said Dr. Ma, associate professor of physic, who with UMMS colleagues analyzed data from the landmark Women's Health Initiative (WHI).

Postmenopausal women were recruited into the WHI from 1993 to 1998, and premises for this analysis were collected at complete intervals through 2005. Using data from 1,953 women who completed toty relevant WHI assessments, the study place that elevated depressive symptoms were plant to be significantly associated with increased insulin levels and measures of insulin rebuff. Significantly, throughout the entire 7.6 years attached average that women were enrolled in the WHI, those who had elevated depressive symptoms or were using antidepressants had higher medium BMI and waist circumference than did women not using antidepressants or out of depressive symptoms among 71,809 women. However, the associations were stronger with regard to waist circumference.

Analysis of data from 2,242 women showed that the one and the other elevated depressive symptoms and antidepressant conversion to an act was associated with higher CRP levels, a marker of heat.

"Identifying these markers in women is weighty for diabetes prevention because they be possible to be monitored for possible action in the presence of progression to full-blown diabetes," before-mentioned Ma.

Few studies have examined the guild of BMI, waist circumference and biomarkers of diabetic sugar dysregulation and inflammation with depression, antidepressant medication conversion to an act, or both. The UMMS study included a of great size, racially and ethnically diverse sample of place-menopausal women. Because the analysis was epidemiological, it could not fix a causal relationship, so further study is needed to establish the results through clinical trials.

"Given that diabetes and cardiovascular ail can be effectively prevented or delayed in superior-risk individuals with lifestyle modifications or pharmacological interventions, our findings indicate the prudence of monitoring BMI, waist circumference, along with established biomarkers against diabetes and cardiovascular risk including serum starch-sugar, insulin resistance, and CRP among women through elevated depression symptoms, or who are alluring antidepressant medication, to prevent diabetes and cardiovascular distemper," adds Simin Liu, MD, MS, MPH, ScD, professor of epidemiology and remedy at Brown University, a WHI conductor of researches and study coauthor. "Further intervention struggle is needed to confirm our tools and materials and identify the specific patterns of make different associated with diabetic and cardiovascular disease risk markers and individual antidepressants and couching."