What is Prozac (fluoxetine)? What are the interest effects of Prozac?
Prozac (fluoxetine) is y antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) rank of drugs. Prozac is mainly used with respect to the treatment of major depression, obsessive-compulsive disturbance, and panic disorder.
The medication was pristine introduced to the American market the agency of Eli Lilly in 1988, and within a few years of its approval Prozac became any of the most widely prescribed antidepressants in the abiding habitation.
It works by blocking the absorption of the neurotransmitter serotonin in the brain. Regulating the aggregate of serotonin helps brain cells remit messages to each other, resulting in a less ill and more stable mood.
Prozac is commonly prescribed on its own, however, it is also used together with the drug olanzapine (Zyprexa) to entertainment manic depression in people suffering from bipolar riotousness - fluoxetine combined with olanzapine is known being of the kind which Symbyax.
Even though there are newer SSRIs like sertraline and citalopram, Prozac is quiet one of the most popular antidepressants advantageous.
The drug is available as a clear, tablet, capsule, and as a delayed-discharge (long-acting) capsule.
Medical uses
Prozac - the pill that completely "revolutionized"
the manipulation of depression
Prozac treatment results in besides neurons being present in a division of the brain called the "notched gyrus" (part of the hippocampal making up).
The medication specifically stimulates the formation of cells called amplifying neural progenitors - the inferior step in the neurogenesis pathway from pedicel cells to mature neurons.
The FDA publicly approves Prozac for acute and vindication treatment of major depressive disorder (MDD), obsessive compulsive malady (OCD), bulimia nervosa, and panic riotousness (with or without agoraphobia).
Prozac and olanzapine in compound is approved for acute treatment of depressive episodes associated by bipolar I disorder and treatment-resistant inactivity.
Some doctors may prescribe Prozac "not on-label" for the treatment of foreboding, premature ejaculation, obesity, and binge-corrosive disorder.
Depression
Brief animation of for what reason Prozac works.
The effectiveness of using Prozac to bargain depression is well established. A 6 week long-winded placebo-controlled trial in depressed adults revealed that Prozac was significantly additional effective at treating depression than placebo - at the same time that measured by the Hamilton Depression Rating Scale (HAM-D).
The medication has also shown promising results in treating children and adolescents sufferance from depression. One study, published in the Archives of General Psychiatry, included 96 children and teenagers with depression (aged 7-17 years) who were each given a daily dose of 20 mg of fluoxetine or placebo the sake of 8 consecutive weeks. The results of the study concluded that "fluoxetine was paramount to placebo in the acute appearance treatment of major depressive disorder in infant and adolescent outpatients with severe, persistive depression."
There are some studies that be the sign of Prozac may not be the greatest part effective antidepressant. Research published in the Cochrane Library, which compared the effectiveness of Prozac to other antidepressants, revealed that Effexor (venlafaxine) and Zoloft (sertraline) were superficially better at treating MDD.
However, it should have existence noted that in some cases Prozac be possible to work well for patients who don't respond to other antidepressants.
Research published in Progress in Neuro-Psychopharmacology and Biological Psychiatry, suggests that more people with depression who fail to be agreeable to to treatment with the SSRIs paroxetine (Paxil) and citalopram (Celexa) - since of a certain genetic variation - may befriend from a switch to Prozac.
Panic put out of place
SSRIs are very useful at treating uneasiness-related illnesses, including panic disorder. SSRIs are usually the primeval choice of medication intervention for violent disorder.
A study published in the Journal of Psychiatry and Neuroscience revealed that of 30 patients diagnosed by panic disorder who received treatment through Prozac "thirty-two percent had cipher panic attacks by week 3" and "by the end of eight weeks of management, 48% of the patients had nothing panic attacks." There was a "momentous reduction in anxiety and phobic avoidance and panic attacks."
Obsessive-compulsive throw into confusion (OCD)
Most SSRIs need to exist taken for more than 11 weeks near the front of people with OCD feel any benefits from the medication. In numerous cases, patients with OCD will have ing put on an SSRI such being of the kind which Prozac for at least a year.
A 13-week placebo-controlled study, published in the Journal of the American Academy of Child and Adolescent Psychiatry, evaluated the "competency and tolerability of fluoxetine in the pointed treatment of child and adolescent OCD" and concluded that "fluoxetine 20 to 60 mg daily was effective and well tolerated with a view to treatment of OCD in this pediatric population."
Bulimia nervosa
Some patients who miss to respond to psychological treatment notwithstanding bulimia may benefit from taking Prozac. Research published in The American Journal of Psychiatry concluded that "fluoxetine may subsist a useful intervention for patients by bulimia nervosa who have not responded adequately to psychological usage."
Adverse effects
The FDA requires Prozac to approach with a black box warning stating that antidepressants may augment the risk of suicide in populace younger than 25.
One of the ut common side effects of Prozac is sexual dysfunction. Many patients noise that after taking Prozac their overall benefit in sex decreases and they commence to have difficulty not only in congruous aroused but also achieving orgasm.
The party effects of Prozac include:
Decreased libido
Anxiety
Abnormal dreams
Sweating
Diarrhea
Asthenia (scarcity of bodily strength)
Rash
Tremor
Nervousness
Flu syndrome
Insomnia (sharp difficulty sleeping)
Sinusitis (inflammation of the mucilaginous membrane)
Somnolence (a state of drowsiness)
Impotence (disqualification to achieve or maintain an building)
Yawning
Dyspepsia (painful or difficult steeping)
Dry mouth
Nausea
Abnormal ejaculation
Vasodilatation (widening of descent vessels)
According to Eli Lilly, Prozac should not subsist taken along with:
Monoamine Oxidase Inhibitors (MAOIs): Pimozide and Thioridazine
Drugs Metabolized through CYP2D6: Fluoxetine
Tricyclic Antidepressants (TCAs)
Caution should be taken when used with drugs that assume the central nervous system, such in the same manner with those belonging to the "benzodiazepines" rank of drugs.
Women who are with child should only take Prozac if the possible benefit justifies the potential risks to the fetus (increasing the jeopardize of poor neonatal adaptation). Breastfeeding under which circumstances pregnant is not advised as fluoxetine have power to pass into the milk.
Discontinuation and subduction
Patients who suddenly stop taking Prozac (or ruin their dose) may experience brain zaps, dizziness, disorder, nightmares, vertigo, insomnia, nausea, and shaking. Abrupt discontinuation of Prozac can furthermore lead to SSRI withdrawal syndrome.
According to a document, published in the Journal of Clinical Psychiatry, titled "Serotonin reuptake inhibitor discontinuation syndrome: a hypothetical exact meaning. Discontinuation Consensus panel":
"SSRI discontinuation symptoms... may rise when an SSRI is abruptly discontinued, when doses are missed, and less not rarely, during dosage reduction. In addition, the symptoms are not ascribable to any other cause and be able to be reversed when the original force is reinstituted, or one that is pharmacologically similar is substituted.
SSRI discontinuation symptoms, in numerous cases, may be minimized by slowly conical antidepressant therapy, but there have been single case reports where symptoms occurred consistently steady through repeated attempts to taper therapy. Physical symptoms contain problems with balance, gastrointestinal and flu-like symptoms, and sensory and drowse disturbances. Psychological symptoms include anxiety and/or hurry, crying spells, irritability and aggressiveness."
Written the agency of Joseph Nordqvist
Copyright: Medical News Today
Not to have ing reproduced without permission of Medical News Today
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